In the past I had only run a CPM chain (Tribal Fusion, Burst, Valueclick, Casale, etc) as well as Adsense. Now I am still doing a chain but I have Gorilla Nation representing my website and bringing in some premium advertisers who are paying mid $x CPM for most campaigns. In the fall when school starts back up, they are planning on selling some custom campaigns (branded micro-sites, homepage takeovers, sponsored promotional contests, etc).
I talk to my account rep on AIM (or phone if its important) a few times a week and he's giving me input on my sites redesign and business plan for a new site I'm working on.
My income also shot up back to what I was used to earning with Tribal Fusion in their glory days (late 2004-early 2005) and then some - so I'm very happy