http://www.bobsgame.com
Guy put 15,000 hours over 5 years into making his own 2d adventure game. Pretty much learned everything from scratch. Designed every pixeled, recorded every sound, and programmed every thing himself.
What's cool is his game picked up a lot of hype and he is now in talks with major publishers to get his game on store shelves.
here is the trailer (oops, copied the code twice, pay no attention to the second one):
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<embed src="http://www.youtube.com/v/vZf2E_wBvng&border=1&color1=0x3a3a3a&color2=0x9999 99&hl=en&fs=1" type="application/x-shockwave-flash" allowfullscreen="true" width="425" height="349"></object>
<object width="425" height="349">
<embed src="http://www.youtube.com/v/vZf2E_wBvng&border=1&color1=0x3a3a3a&color2=0x9999 99&hl=en&fs=1" type="application/x-shockwave-flash" allowfullscreen="true" width="425" height="349"></object>