Although it is good to get the high paying offers, don't forget that just because they are high paying could also mean that it is hard for you to convert your clicks into earnings. Also, you have to consider the network that they are on aswell.
Offers that tie directly to your customers/visitors intentions in visiting your site.
If your site is an automotive site then obviously you would expect a tire offer to do better than a dentist offer.
The problem with so many CPA offers is the amount of information they collect before you get paid. And so many of them are just BS scams that most people are finally wising up.
Find offers that tie directly with your content and then test. then test. then test.