I'm a huge fan of Nettuts and the Envato crew and it looks like they just finished up a pretty neat series on how to fully design and code up a website from scratch. Probably worth working through if you're just getting started so that you can get an idea of what goes into things.
Iconify: A Complete Website | Webdesigntuts+
(I haven't worked through it myself but I did browse it and it looks quite good)
Iconify: A Complete Website | Webdesigntuts+
(I haven't worked through it myself but I did browse it and it looks quite good)