On the piracy side of things - I can tell you most people can and will try to get it for free. I have a fairly small niche (sold 5k max copies to date. Blame my poor marketing skills) I have people visiting my site with the keywords "my ebook name + torrent". Makes me wanna put a fake torrent out there that freaks them out telling them their IP has been logged for trying to use a fake copy w/o a license and then urge them to go buy a legal one. Unless you got yours locked down hard (mine is pretty locked down) this will be a problem. My customers are fairly non-saavy (think - it downloaded and I don't know where it is) and yet they still try to get around paying. Not a huge issue, but once you've spent a few thousand on an IP lawyer you will start to get a touch paranoid.
The solution to this is to convert your eBook into an online course, complete with accompanying video material, worksheets, etc (provided your ebook is sort of a "how to" kind of deal).
Offer a stripped down version of your course as a PDF/Kindle/Mobi ebook for customers who want to learn on the go.
If people pirate the ebook version, they'll be disappointed that they don't get access to some key material, and might end up buying your course.
The only solution I can really think of that circumvents piracy. As a shameless pirate myself, I can tell you this method works (nothing worse then feeling like you're not getting the TOTAL value of something helpful because you're a cheap fuck).